Localized ERK activation can trigger mitotic entry in Drosophila embryo.
Movie shows mitotic waves initiated from the center of optoSOS embryo. optoSOS allows for ectopic activation of the RAS/ERK pathway in response to optical stimulation. The Red box indicates the illuminated region, where ERK signaling is activated. Histone-mIFP is used to visualize the nuclei. Interphase and M-phase nuclei are marked by yellow and blue, respectively. Scale bar = 50 µm. Taken from Yang L et al. 2024 (Dev Cell).